Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

… Our key defense against the COVID-19 pandemic is neutralizing antibodies

… Recent emerging viral variants have raised concern

… to escape antibody neutralization

… four antibodies from early-outbreak convalescent donors

… potent against 23 variants, including variants of concern

… Our study demonstrates that convalescent subjects previously infected with ancestral variant SARS-CoV-2 produce antibodies that cross-neutralize emerging VOCs with high potency