THREE-QUARTERS of population under 18 have antibodies NOT produced in response to COVID-19 vaccines

… Traditional methods of disease surveillance do not capture all COVID-19 cases

… some are asymptomatic, not diagnosed, or not reported

… U.S. trends in infection-induced SARS-CoV-2 seroprevalence during September 2021–February 2022

… tested for anti-nucleocapsid (anti-N) antibodies, which are produced in response to infection

… are not produced in response to COVID-19 vaccines

… During December 2021–February 2022, overall U.S. seroprevalence increased from 33.5% to 57.7%

… increased from 44.2% to 75.2% among children aged 0–11 years

… from 45.6% to 74.2% among persons aged 12–17 years

… from 19.1% to 33.2% among those aged ≥65 years

… As of February 2022, approximately 75% of children and adolescents had serologic evidence of previous infection with SARS-CoV-2

… The greatest increases in seroprevalence during September 2021–February 2022, occurred in the age groups with the lowest vaccination coverage