RISKS GREATER than benefits (avoid hospitalizations)
… In 2020, prior to COVID-19 vaccine rollout, the Coalition for Epidemic Preparedness Innovations and Brighton Collaboration
… created a priority list, endorsed by the World Health Organization, of potential adverse events relevant to COVID-19 vaccines
… We leveraged the Brighton Collaboration list to evaluate serious adverse events of special interest observed in phase III randomized trials of mRNA COVID-19 vaccines
… Results: Pfizer and Moderna mRNA COVID-19 vaccines were associated with an increased risk of serious adverse events of special interest
… an absolute risk increase of 10.1 and 15.1 per 10,000 vaccinated
… he excess risk of serious adverse events of special interest surpassed the risk reduction for COVID-19 hospitalization relative to the placebo group in both Pfizer and Moderna trials (2.3 and 6.4 per 10,000 participants, respectively)
